Total Pageviews

Tuesday 28 May 2013

Carcinoid Tumor of Appendix


Carcinoid Tumor of  Appendix

The word Carcinoid means ‘carcinoma like appearance’.
 In the the small bowel Carcinoid tumors arise from Kulchistsky cells located in the crypts of Lieberkuhn.
Kulchistsky cells are also called Argetaffin cells as these cells can be stained by the silver compounds.
Usual age group of Carcinoid Tumor  : Fifth/Sixth Decade of Life
The Most Common Siteof Carcinoid Tumor  : Appendix
Vermiform Appendix

Other Sites of G I Carcinoid Tumor  : Small Intestine, Rectum, Colon, Stomach
Non Intestinal sites of Carcinoid Tumor  : Lungs, Pancreas, Thymus, Ovary, Testis, Biliary tract
Embryologic Classification of Carcinoids
1.     Foregut Carcinoids-Lungs, Stomach & Pancreas
2.     Midgut Carcinoids-Small Intestine & Appendix
3.     Hindgut Carcinoids-Colon & Rectum
Carcinoid Syndrome
  • Seen in 10% of cases of
  • Due to release of ,Serotonin, Histamine, Bradykinin, Prostaglandin
  • Clinical features : Flushing, Watery Diarrhea, Sweating, Wheezing, Breathlessness, Abdominal pain and Hypotension.
Investigations
Urinary 5-HIAA, Chromogranin A
CT Scan Abdomen
CT Scan Chest-for Bronchial Carcinoids
Treatment of Carcinoid Tumor Appendix
If the Carcinoid Tumor Appendix is less than 2 cm and is away from the base, the treatment is Appendicectomy.
Open Appendicectomy

If the Carcinoid Tumor Appendix is close to the base of the appendix or the size is more than 2cm the treatment is Right Hemi Colectomy.

What is Carcinoid Crisis?
Life threatening form of Carcinoid syndrome.
Usually precipitated by Anesthesia, Surgery, Chemotherapy
Prophylactic agent used prevent Carcinoid crisis is Octreotide ( Somatostatin Analogue)
 





1 comment:

  1. antibodies and synthetic chemistry. Our extensive expertise is translated into high quality products and world-class services to ensure the maximum satisfaction of the customers. Chromogranin A

    ReplyDelete